Not to be confused with Tequila, Mezcal is a distilled spirit also made from the agave plant. The difference between the two is that Mezcal is made from a variety of different types of agave grown throughout eight regions in Mexico, whereas Tequila can only be made from the blue agave plant, which is grown in the Jalisco region. Mezcal must contain 80% agave as a minimum but premium producers use 100%.